Studies on the Inhalation Toxicity of Dyes Present in Colored Smoke Munitions. Phase III, Studies: Four-Week Inhalation Exposures of Rats to Dye Aerosols.
LOVELACE BIOMEDICAL AND ENVIRONMENTAL RESEARCH INST ALBUQUERQUE NM INHALATION TOXICOLOGY RESEARCH INST
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The USAMBRDL has an interest in the potential inhalation toxicity of yellow dye SY and a yellowgreen dye mixture SYSG used in colored smoke munitions. Rats were exposed by inhalation to aerosols of SY or SYSG generated in a respirable particle size range for 6 hrday, 5 daysweek for 4 weeks. Nominal exposure concentrations selected for both dye exposures were 0, 10, 50, and 250 mgcum. Animals exposed to the highest concentration of SY 230mgcum showed only a slight decrease in weight gain 8 percent and mild respiratory function changes, with no observable histopathological lesions. Exposure to the lower concentrations of SY dye elicited no observed response. Animals exposed to the highest level of SYSG dye 210 mgcum displayed signs of pulmonary inflammation with histopathological evidence of mild Type II pulmonary epithelial cell hyperplasia and proliferation of foamy alveolar macrophages. Some of the animals exposed to the medium concentration of SYSG dye mixture 49 mgcum showed similar signs. Thus, the lowest toxic exposure concentration of SY dye is or 230 mgcum and that of SYSG dye is or 50 mgcum under the exposure regime used. Originator supplied keywords include Solvent Yellow Solvent Green 2-2-quinolyl-1,3-indandione, 1,4-di-p-toluidinoanthraquinone.
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