Accession Number:

ADA156642

Title:

Study of Toxic and Antigenic Structures of Botulinum Neurotoxins.

Descriptive Note:

Annual rept. 1 Feb-31 Aug 1984, Final rept. 1 Aug 1980-31 Aug 1984

Corporate Author:

WISCONSIN UNIV-MADISON

Personal Author(s):

Report Date:

1985-02-01

Pagination or Media Count:

14.0

Abstract:

Amino acid compositions of botulinum neurotoxin NT types A, B, E and F were determined. The heavy and light chains of types A, B and E NT were separated, purified, and analyzed for amino acid compositions and partial N- terminal sequence. Selective modification of tyr, his and arg residues and also carboxyl and amino groups of types A and E NT demonstrated the role of these amino acid residues in toxicity and antigenicity. Type E NT completely detoxified following modification of his, tyr or amino groups has potential as a toxoid. Effects of types A and B NT on rat neuromuscular junctions appear non- identical. Additional keywords immunology bacterial toxins.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE