Genetic and Physiological Control of Protective Antigen Synthesis by Bacillus anthracis
Annual progress rept. no. 5, 1 Jan-31 Dec 1984
MASSACHUSETTS UNIV AMHERST DEPT OF MICROBIOLOGY
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The primary objective of the research is to gain information and to develop genetic systems that will contribute to the development of an improved vaccine for anthrax. Genetic and physiological factors controlling the synthesis and accumulation of protective antigen as well as the two other components of anthrax toxin are being investigated. During the past year attention was focused on 1 further development and application of a mating system for transfer of plasmids among Bacillus species, and 2 studies of a newly discovered plasmid which encodes capsule formation in B. anthracis. The mating system for transfer of plasmids among B. anthracis, B. cereus, and B. thuringiensis is very useful for assessing the biological significance of plasmids found in the three species. Originator supplied keywords include Bacillus anthracis Anthrax protective antigen Anthrax toxin B. anthracis plasmid.