Immunologic Control of Diarrheal Disease Due to Enterotoxigenic Escherichia coli
Annual rept. 1 Jan-31 Dec 1983
MARYLAND UNIV BALTIMORE CENTER FOR VACCINE DEVELOPMENT
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A long-term program has been undertaken to develop effective immunizing agents to control enterotoxigenic Escherichia coli ETEC diarrheal disease. Acute travelers diarrhea is a major cause of loss of effectiveness in United States Military personnel assigned in less-developed areas and that ETEC are the most frequent etiologic agent of acute travelers diarrhea. Two separate approaches are being followed to develop vaccines against ETEC. One involves purification of colonization factor antigen fimbriae pili and their use as oral vaccines. The second approach involves a genetically-engineered non- enterotoxigenic strain to be used as an oral vaccine. Another major pathogen responsible for travelers diarrhea and dysentery in military personnel is Shigella. A close collaboration with the Department of Bacterial Diseases of the Walter Reed Army Institute of Research involves clinical studies to access the safety, immunogenicity and efficacy of candidate oral Shigella vaccines developed by Dr. S.B Formal and co-workers in the Department of Bacterial Diseases at WRAIR.
- Medicine and Medical Research