Accession Number:

ADA155723

Title:

Carcinogenesis of Nitrated Toluenes and Benzenes Skin and Lung Tumor Assays in Mice

Descriptive Note:

Final rept. Nov 1979-Mar 1983

Corporate Author:

OAK RIDGE NATIONAL LAB TN BIOLOGY DIV

Report Date:

1985-05-01

Pagination or Media Count:

34.0

Abstract:

A series of nitrated toluenes and benzene were tested for their capability to act as initiators, promoters or complete carcinogens in mouse skin. 2,6-dinitrotoluenes and 2-nitrotoluene were found to have weak skin tumor initiating activity. 2,4-dinitrotoluene, 2,6-dinitrotoluenes and 1,3,5- trinitrobenzene produced historical changes in skin which usually are produced by promoting agents this finding suggests that the three compounds could have skin tumor promoting activity. However, a firm conclusion can only be reached following appropriate in vivo tests. In the lung tumor assay, none of the chemicals tested gave an unequivocal positive response. A borderline positive result for unpurified 2,6-dinitrotoluene could not be repeated when the purified compound was reassayed in the same assay.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE