Carcinogenesis of Nitrated Toluenes and Benzenes Skin and Lung Tumor Assays in Mice
Final rept. Nov 1979-Mar 1983
OAK RIDGE NATIONAL LAB TN BIOLOGY DIV
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A series of nitrated toluenes and benzene were tested for their capability to act as initiators, promoters or complete carcinogens in mouse skin. 2,6-dinitrotoluenes and 2-nitrotoluene were found to have weak skin tumor initiating activity. 2,4-dinitrotoluene, 2,6-dinitrotoluenes and 1,3,5- trinitrobenzene produced historical changes in skin which usually are produced by promoting agents this finding suggests that the three compounds could have skin tumor promoting activity. However, a firm conclusion can only be reached following appropriate in vivo tests. In the lung tumor assay, none of the chemicals tested gave an unequivocal positive response. A borderline positive result for unpurified 2,6-dinitrotoluene could not be repeated when the purified compound was reassayed in the same assay.