Korean Hemorrhagic Fever (Hemorrhagic Fever with Renal Syndrome (HFRS)).
Final rept. 1 Jan-31 Dec 82,
KOREA UNIV SEOUL DEPT OF MICROBIOLOGY
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This report presents the results of seroepidemiologic studies of laboratory infections with Hantaan virus in animal rooms of institutes in Korea and Japan during last 5 years, and isolation of Hantaan virus from urban rats caught in Incheon harbor and Tokyo harbor and, isolation of 7 strains of Hantaan virus from lung tissues of rodent in tissue culture cells. From 1975 to 1981, 126 cases of Hemorrhagic Fever with Renal Syndrome HFRS, of which one was fatal, had occurred in 22 animal rooms of research laboratories in Korea and Japan. Among colonized laboratory rats of the animal rooms, 71 Korea and 40 Japan had antibodies to Hantaan virus. In Korea, 23 of those 71 were proven to have pulmonary viral antigen and 7 strains of Hantan virus were isolated from those rats. 203 urban rats caught in Tokyo harbor yielded 5 isolates of Hantaan virus of which one strain was propagated in Vero E-6 cells. 215 urban rats caught in Incheon harbor yielded 14 isolates of Hantaan virus of which one strain was propagated in vero E-6 cells and found to have both of the antigenic characteristics as that of Korean agent and NE agent. Five strains of Hantaan virus were isolated and propagated in Vero E-6 cells three strains are from blood of HFRS patients and two strains from wild Apodemus mice. Originator supplied keywords include R. norvegicus. Immunofluorescent antibody technique, Vero E-6 cells, Laboratory infection.
- Anatomy and Physiology
- Medicine and Medical Research