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Molecular Toxicology of Chromatin: The Role of Poly(ADP-Ribose) in Gene Control.
Annual progress rept. Oct 83-31 Dec 84,
CALIFORNIA UNIV SAN FRANCISCO
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This report pertains to the following research projects Chemical and macromolecular structure of polyADP-ribose1. HPLC-isolation of polyADP-ribose.. 2. Fractionation, size analysis branching of poly ADP-ribose by HPLC and chemical analysis of subunits. 3. Mathematical model of polymerization of ADP-ribose. II. Biosystems. III. Molecular studies on purified polyADP-ribosylation in cellular and subcellular systems. III. Molecular studies on purified polyADP-ribose polymerase system. 1. DNA-association of benzamide. 2. The role of lysine residues in the catalysis and DNA binding of polyADP-ribosepolymerase. IV. Cell transformation and poly ADP-ribosylation. 1. Inhibition of carcinogen initiated transformation. 2. Ultraviolet light induced transformation and its inhibition.
APPROVED FOR PUBLIC RELEASE