Accession Number:

ADA151232

Title:

Study of Toxic and Antigenic Structures of Botulinum Neurotoxins

Descriptive Note:

Annual rept. 1 Aug 1980-28 Feb 1983

Corporate Author:

WISCONSIN UNIV-MADISON FOOD RESEARCH INST

Personal Author(s):

• DasGupta, Bibhuri R.

Report Date:

1983-09-01

Pagination or Media Count:

8.0

Abstract:

The immunologically distinct botulinum neurotoxin NT types A, B, E, and F were defined in terms of amino acid composition number of residuesprotein molecule. The subunit heavy and light chains of type A NT were separated and their amino sequences were partially determined. Histidine residues of type A and E appear critical for toxicity but not for serological reactivity. The paralyzing effect of type B has a shorter duration of action, than type A, at the rat neuromuscular junction but less effectively antagonized by 3,4-diaminopyridine.

Descriptors:

• *TOXICITY
• *IMMUNOLOGY
• *BACTERIAL TOXINS
• *CLOSTRIDIUM BOTULINUM
• RATS
• MOLECULES
• PROTEINS
• TIME
• ANTIGENS
• RESIDUES
• AMINO ACIDS
• PARALYSIS
• HISTIDINE

Subject Categories:

• Medicine and Medical Research
• Toxicology
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE