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Study of Toxic and Antigenic Structures of Botulinum Neurotoxins
Annual rept. 1 Aug 1980-28 Feb 1983
WISCONSIN UNIV-MADISON FOOD RESEARCH INST
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The immunologically distinct botulinum neurotoxin NT types A, B, E, and F were defined in terms of amino acid composition number of residuesprotein molecule. The subunit heavy and light chains of type A NT were separated and their amino sequences were partially determined. Histidine residues of type A and E appear critical for toxicity but not for serological reactivity. The paralyzing effect of type B has a shorter duration of action, than type A, at the rat neuromuscular junction but less effectively antagonized by 3,4-diaminopyridine.
APPROVED FOR PUBLIC RELEASE