Synthesis of New Prophylactic Antiradiation Drugs.
Annual rept. 1 Aug 83-31 Jul 84,
ILLINOIS UNIV AT THE MEDICAL CENTER CHICAGO DEPT OF MEDICINAL CHEMISTRY
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Syntheses of 1-amino-2-1-phenyl-2-adamantylethane, 1-phenyl-4-adamantyl-methylamine and 1-amino-2- 4-1-adamantylphenyl ethane and their transformation to the disulfides of the corresponding 2-mercaptoacetamidines are described. 4-Epoxymethyleneprotoadamantane was converted in 2 steps to 2-phenyl-1-adamantanecarboxylic acid, a precursor for the planned synthesis of 2-phenyl-1-adamantylalkylamines.