Accession Number:

ADA149351

Title:

Preliminary Assessment of Relative Toxicity and Mutagenic Potential of 1 Nitroso-3,5-Dinitro-1,3,5-Triazacyclohexane (Mononitroso-RDX)

Descriptive Note:

Final rept. Oct 1982-Sep 1984

Corporate Author:

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1984-09-01

Pagination or Media Count:

15.0

Abstract:

The munitions component, 1-nitroso-3, 5-dinitro-1,3,5- triazacyclohexane Mononitroso-RDX, was assessed for its relative irritant, skin sensitization, and mutagenicity potential. It showed no potential for eye or skin irritation in rabbits following a single application. It did not prove to be a skin sensitizer to guinea pigs. Mononitroso-RDX showed positive mutagenic activity in three of four in vitro bioassays. This finding, in addition to its implicating chemical structure, would earmark the chemical as a suspect mutagen andor carcinogen. Further testing is recommended to establish human risk. Interim protection and monitoring of operational personnel is also recommended until mutagenictoxicological risks are resolved.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE