Accession Number:

ADA149290

Title:

Ultrasensitive Detection of Chemical Substances

Descriptive Note:

Quarterly rept. 1 Jun-31 Aug 1984

Corporate Author:

NEW MEXICO UNIV ALBUQUERQUE SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1982-07-01

Pagination or Media Count:

4.0

Abstract:

We have continued in our efforts to quantitate the relative binding constants of our monoclonal antibodies and in reducing noise factors. We were able to measure the intrinsic affinity constant of protein A purified antibody specific for AChE-DFP conjugate. Since affinity constants reflect the dissociation and association constant, and association constants will be similar for antibodies to a particular antigen, we can test our monoclonal antibodies for their relative strength of binding using affinity constant calculations. Thus, for the time being, we see no essential need to calculate dissociation constants directly.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE