Symposia Summary of the International RES Congress (10th) held at Ito, Japan on 2-7 September 1984.
Final rept. 1 Aug 84-1 Jul 85,
RETICULOENDOTHELIAL SOCIETY AUGUSTA GA
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Many facets of macrophage function were reviewed which secure for this cell a central role in both the stimulation and expression of immune responses. The variety and complexity of effector activities expressed by macrophages was discussed, both in a resting state and following stimulation with soluble products released at sites of inflammation and immune reactions. Many of these effector reactions require interaction of the stimulating agent with receptors present on the macrophage cell membrane. Some receptors, such as the antibody Fc receptors, induce not only internalization of the immune complex, but secretion of a variety of reactive substances complement components, clotting factors, enzymes, reactive oxygenion, etc. other receptors, such as the complement C3 and mannosyl receptors, stimulate only phagocytosis. Regulation of phagocytosissecretion may be through alteration in free non-mitochondrial calcium. One secretory product that induces death of certain intracellular microorganisms and extracellular tumor targets is reactive oxygenion.
- Medicine and Medical Research