Blood Substitutes: Effects on Drug Pharmacokinetics.
Annual rept. no. 1, 15 Sep 81-14 Sep 82,
KANSAS UNIV MEDICAL CENTER KANSAS CITY DEPT OF MEDICINE
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The effect of exchange transfusion with Fluosol DA 20 FDA or stroma-free hemoglobin SFH on the pharmacokinetics of penicillin and diazepam and on the effectiveness of penicillin therapy of pneumococcal infection in rats was determined. FDA prolongs the half-life of penicillin and does not alter the pharmacokinetics of diazepam. SFH increases the volume of distribution of both penicillin and diazepam and increases the half-life of diazepam. Penicillin only suppresses pneumococcal infection in FDA transfused rats but cures pneumococcal infection in SFH transfused rats.