Accession Number:

ADA148928

Title:

Blood Substitutes: Effects on Drug Pharmacokinetics.

Descriptive Note:

Annual rept. no. 1, 15 Sep 81-14 Sep 82,

Corporate Author:

KANSAS UNIV MEDICAL CENTER KANSAS CITY DEPT OF MEDICINE

Personal Author(s):

Report Date:

1982-09-01

Pagination or Media Count:

21.0

Abstract:

The effect of exchange transfusion with Fluosol DA 20 FDA or stroma-free hemoglobin SFH on the pharmacokinetics of penicillin and diazepam and on the effectiveness of penicillin therapy of pneumococcal infection in rats was determined. FDA prolongs the half-life of penicillin and does not alter the pharmacokinetics of diazepam. SFH increases the volume of distribution of both penicillin and diazepam and increases the half-life of diazepam. Penicillin only suppresses pneumococcal infection in FDA transfused rats but cures pneumococcal infection in SFH transfused rats.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE