Accession Number:

ADA148868

Title:

Inhalation Toxicity of Manganese Dioxide and a Magnesium Oxide-Manganese Dioxide Mixture.

Descriptive Note:

Final rept. Nov 82-Jun 83,

Corporate Author:

BROOKHAVEN NATIONAL LAB UPTON NY

Personal Author(s):

Report Date:

1984-09-01

Pagination or Media Count:

78.0

Abstract:

This report describes 1 The development, characterization and use of a fluidizing bed aerosol generator 2 Characterization of the mass and particle size distribution of aerosolized manganese dioxide MnO2 in 1.4 cu m inhalation chambers and 3 The results of a range-finding inhalation toxicity study of rats exposed to manganese dioxide dust. The major biologic response observed in the range-finding study was the suggestion of long-term pulmonary fibrosis. Recommendations of doses and biologic endpoints for a subchronic study are made.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE