Inhalation Toxicity of Manganese Dioxide and a Magnesium Oxide-Manganese Dioxide Mixture.
Final rept. Nov 82-Jun 83,
BROOKHAVEN NATIONAL LAB UPTON NY
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This report describes 1 The development, characterization and use of a fluidizing bed aerosol generator 2 Characterization of the mass and particle size distribution of aerosolized manganese dioxide MnO2 in 1.4 cu m inhalation chambers and 3 The results of a range-finding inhalation toxicity study of rats exposed to manganese dioxide dust. The major biologic response observed in the range-finding study was the suggestion of long-term pulmonary fibrosis. Recommendations of doses and biologic endpoints for a subchronic study are made.