Immune Dysfunctions and Abrogation of the Inflammatory Response by Environmental Chemicals.
Annual rept. 1 Jul 83-30 Jun 84,
OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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Experiments done during FY 1983-1984 provide further evidence 1-1 that UDMH dimethylhydrazine enhances the immune system. The allogeneic mixed lymphocyte reaction MLR was enhanced by UDMH both when splenocytes in the reaction were incubated in the presence of UDMH, and when splenocytes from mice treated with UDMH were assayed in the MLR. The enhancement was most notable both in vivo and in vitro when the macrophage and B-cell enriched simulator population was exposed to UDMH. This supports our hypothesis that macrophage suppressor activity is abrogated by UDMH, possibly by reduction of prostaglandin synthesis by the macrophage. Other experiments indicate that this effect is not due to alterations in intracellular cyclic nucleotide levels in splenocytes.
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