Morbidity and Mortality Associated with Exposure to Otto Fuel II in the U.S. Navy 1966-1979
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
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This investigation assessed whether the morbidity and mortality previously associated with nitrated esters would be found in Torpedomans Mates TM potentially exposed to Otto Fuel II. In the initial analysis, illness andor death in 16 selected cardiovascular, neurologic, and toxic diagnoses were compared among potentially exposed TMs and appropriate control groups during the period 1966-1979. Hospitalization rates and confidence intervals were calculated and survival tables were used to calculate the probability of hospitalization. Estimates of age and occupational group-specific relative risks were then made to determine if there were any significant risk differences between study groups. There was no statistically significant excess of CVS morbidity or mortality in TMs. Lack of reliable PNEC information prior to 1970 may have introduced a selection bias that obscured the true Otto Fuel exposure experience of TMs. Additionally, the wide spectrum of disease conditions that may be associated with the use of Otto Fuel have known non-occupational risk factors and etiologies that could be confounding factors. To overcome these biases, a second analysis focused on three CVS Cardiovascular System, conditions acute myocardial infarction, angina pectoris and cardiac arryhthmias, known to be associated with analogous nitrated esters. Risk assessment analysis for the ten-year period 1970-1979 suggests that exposed TMs have a significantly greater risk of a CVS related hospitalization compared to other TMs and fire control technicians.
- Medicine and Medical Research