Genetic and Physical Structure of Salmonella-coli Phage Hybrids and Development of New Generalized Transducing Hybrid Phages for E. Coli.
Final rept. 1 Jan 74-31 Aug 83,
HAHNEMANN UNIV SCHOOL OF MEDICINE PHILADELPHIA PA
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Hybrids between unrelated bacteriophages are invaluable models to study genetic evolution, gene regulation, and morphogenesis. For many years studies in my laboratory have been focused on the mechanism of hybrid formation between evolutionary diverse phages. Collaborative studies with a group of Walter Reed Army Institute of Research began searching for E. coli-S. typhimurium recombinants in 1971. After isolating E. coli-S. typhimurium hybrids which are common hosts for the various coli and Salmonella phages, we developed efficient selective methods of hybrids between Salmonella and E. coli phages and have isolated numerous hybrid phages in a tailor made fashion by varying the selection procedure.