Accession Number:

ADA148650

Title:

The Use of ATP-MgCl2 in the Treatment of Injury and Shock.

Descriptive Note:

Annual rept. 1 Sep 81-31 Aug 82,

Corporate Author:

YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1982-08-31

Pagination or Media Count:

16.0

Abstract:

In normal as well as hypovolemic awake dogs, cardiac output can be increased significantly by infusion of ATP-MgCl2 intravenously at rates of 0.5-2.5mgkgmin. The higher doses of ATP-MgCl2 may have detrimental hemodynamic effects, however, such effects are immediately reversible by ceasing ATP-MgCl2 infusion. Moreover, the deleterious hemodynamic effects of very high doses of ATP-MgCl2 can be markedly ameliorated by atropine. Infusion of ATP-MgCl2 did not affect hepatic or renal function, myocardium or blood chemistry after infusion or even after a prolonged period of time. Infusion of even massive doses of ATP-MgCl2 have no ill effects on the survival of dogs.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE