The Use of ATP-MgCl2 in the Treatment of Injury and Shock.
Annual rept. 1 Sep 81-31 Aug 82,
YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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In normal as well as hypovolemic awake dogs, cardiac output can be increased significantly by infusion of ATP-MgCl2 intravenously at rates of 0.5-2.5mgkgmin. The higher doses of ATP-MgCl2 may have detrimental hemodynamic effects, however, such effects are immediately reversible by ceasing ATP-MgCl2 infusion. Moreover, the deleterious hemodynamic effects of very high doses of ATP-MgCl2 can be markedly ameliorated by atropine. Infusion of ATP-MgCl2 did not affect hepatic or renal function, myocardium or blood chemistry after infusion or even after a prolonged period of time. Infusion of even massive doses of ATP-MgCl2 have no ill effects on the survival of dogs.
- Anatomy and Physiology
- Medicine and Medical Research