Accession Number:
ADA148650
Title:
The Use of ATP-MgCl2 in the Treatment of Injury and Shock.
Descriptive Note:
Annual rept. 1 Sep 81-31 Aug 82,
Corporate Author:
YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
Personal Author(s):
Report Date:
1982-08-31
Pagination or Media Count:
16.0
Abstract:
In normal as well as hypovolemic awake dogs, cardiac output can be increased significantly by infusion of ATP-MgCl2 intravenously at rates of 0.5-2.5mgkgmin. The higher doses of ATP-MgCl2 may have detrimental hemodynamic effects, however, such effects are immediately reversible by ceasing ATP-MgCl2 infusion. Moreover, the deleterious hemodynamic effects of very high doses of ATP-MgCl2 can be markedly ameliorated by atropine. Infusion of ATP-MgCl2 did not affect hepatic or renal function, myocardium or blood chemistry after infusion or even after a prolonged period of time. Infusion of even massive doses of ATP-MgCl2 have no ill effects on the survival of dogs.
Descriptors:
Subject Categories:
- Anatomy and Physiology
- Medicine and Medical Research
- Pharmacology