Synthesis of New Prophylactic Antiradiation Drugs.
Annual rept. 1 Aug 82-31 Jul 83,
ILLINOIS UNIV AT THE MEDICAL CENTER CHICAGO DEPT OF MEDICINAL CHEMISTRY
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This report is divided into four 4 major sections. Each section addresses a phase of the syntheses of adamantyl aryl alkylamines where the amine is incorported into an N-substituted 2-mercaptoacetamidine, or a derivative of the sulfide function. The first part describes the efforts in the 1-aryl-3-adamantyl-methylamine series where the aryl group is 2-thienyl. The next section is devoted to the practical approaches to the synthesis of 1-aryl-2-adamantylalkyl-amines. The work culminates in the preparation of the first member, namely, 1-phenyl-2-adamantylmethylamine. The third section describes some preliminary work on the preparation of 1-aryl-4-adamantylalkylamines. And, the last section reports the synthesis of 4-1-adamantylbenzylamines and its conversion to the disulfide based on N-4-1-adamantylbenzyl-2-mercaptoacetamidine.