Accession Number:

ADA148649

Title:

Synthesis of New Prophylactic Antiradiation Drugs.

Descriptive Note:

Annual rept. 1 Aug 82-31 Jul 83,

Corporate Author:

ILLINOIS UNIV AT THE MEDICAL CENTER CHICAGO DEPT OF MEDICINAL CHEMISTRY

Personal Author(s):

Report Date:

1983-08-01

Pagination or Media Count:

46.0

Abstract:

This report is divided into four 4 major sections. Each section addresses a phase of the syntheses of adamantyl aryl alkylamines where the amine is incorported into an N-substituted 2-mercaptoacetamidine, or a derivative of the sulfide function. The first part describes the efforts in the 1-aryl-3-adamantyl-methylamine series where the aryl group is 2-thienyl. The next section is devoted to the practical approaches to the synthesis of 1-aryl-2-adamantylalkyl-amines. The work culminates in the preparation of the first member, namely, 1-phenyl-2-adamantylmethylamine. The third section describes some preliminary work on the preparation of 1-aryl-4-adamantylalkylamines. And, the last section reports the synthesis of 4-1-adamantylbenzylamines and its conversion to the disulfide based on N-4-1-adamantylbenzyl-2-mercaptoacetamidine.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE