Accession Number:

ADA148644

Title:

Altitude Exposure and the Role of Hypoxia and Arginine Vasopressin in Cerebral Fluid Dynamics.

Descriptive Note:

Annual rept. Dec 81-28 Feb 83, Final rept. 1 Mar 81-28 Feb 83,

Corporate Author:

SAINT LOUIS UNIV MO

Personal Author(s):

Report Date:

1983-05-31

Pagination or Media Count:

39.0

Abstract:

Through exposure of rabbits V10 to barometric pressures equivalent to that encountered at 18,000 ft for 6-8 hr, we found no increase in water content of various parts of the brain temporal, parietal, frontal cortices dien cephalon, mid-brain, hindbrain, cerebellum. Repeated exposure of rabbits N57 to hypoxia equivalent to 8,000 to 16,000 ft generally lead to an increase in CSF pressure. However, we found no influence of hypoxia upon CSF arginine vasopressin contents. When injected into the lateral ventricles of rabbits, arginine vasopressin, norepinephrine, prostaglandin E2 and prostaglandin F 1 alpha did not influence CSF pressures. Angiotensin II generally caused an increase in CSF pressure while saralasin, an AII blocker generally caused a decrease in CSF pressure when given by itself and prevented a rise in CSF pressure if given before AII. Injection of acetazolamide ito the lateral ventricles did not consistently alter CSF pressures but when given systematically, acetazolamide caused a decreae in CSF pressure in two thirds of the treated animals.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE