Altitude Exposure and the Role of Hypoxia and Arginine Vasopressin in Cerebral Fluid Dynamics.
Annual summary rept. 1 Mar-1 Dec 81,
SAINT LOUIS UNIV MO
Pagination or Media Count:
Through exposure of rabbits 10 to barometric pressures equivalent to that encountered at 18,000 ft for 6-8 hours, we found no increase in water content of various parts of the brain temporal, parietal, frontal cortices thalamus, midbrain, hindbrain, cerebellum. We have found that the cerebrospinal fluid CSF pressure significantly increases when rabbits are exposed to hypoxia. We conclude that the initial change in CSF dynamics with hypoxia is an increase in CSF pressure. At present we do not know if this increase is due to an increase in CSF production andor a decrease in clearance of CSF. The role of arginine vasopressin in this process is under study. Originator-supplied keywords include Cerebroventricular cannulation.
- Anatomy and Physiology
- Stress Physiology