Genetic Characterization of Insect Vectors of Disease.
Annual rept. 1 Sep 81-31 Aug 82,
YALE UNIV NEW HAVEN CONN
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The proposed projects involved population genetic analysis of Aedes aegypti. The main technique employed is gel electrophoresis of soluble proteins followed by staining for specific enzyme activity. Using this method we have identified 22 enzyme loci in this mosquito, of which 11 are particularly variable polymorphic and useful for our studies. The objectives of the research are to study allelic variation at these loci in order to answer the following questions about A. aegypti 1 How genetically variable are populations 2 How much genetic differentiation exists between populations 3 Can we define areas within the distribution of A. aegypti which have populations genetically similar and differentiated from other areas 4 Do the world-wide patterns of genetic variation in this vector correspond in any way to patterns of diseases transmitted by A. aegypti