Research and Development of Wound Dressing in Maxillofacial Trauma.
Annual summary rept. 1 Oct 81-31 May 82,
BIOTEK INC WOBURN MA
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Because of the natural molecular weight distribution of poly-L--lactide polymerization, batches can be blended with viscosities as disparate as R.S.v. 1.2 or - 0.6 dlg. Fabrics are prepared by spraying a solution of polymer and drug. Powders are prepared by grinding a cast film of polymer and drug with dry ice. Materials were characterized by drug content and timed release, and by SEM and EDAX energy dispersive analysis of X-rays. Povidone-iodine fabrics were prepared from 20 to 75 drug. With less drug the fabric was more fibrous, but drug release was less. A 40 drug fabric was chosen for further testing. EDAX of these fabrics showed less iodine on the surface than in the total fabric. Anesthetic fabrics were prepared with benzocaine, bupivacaine-HCl, etidocaine-HCl, and lidocaine base, hydrochloride, and hydrosulfate. Generally the base form of the anesthetics deliver drug in a more continuous manner than the salt forms, and etidocaine-HCl release is more continuous than bupivacaine-HCl release.
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