Neurophysiological Bases of Event-Related Potentials.
Annual rept. no. 2, 1 May 83-30 Apr 84,
SRI INTERNATIONAL MENLO PARK CA LIFE SCIENCES DIV
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In order to more fully understand the physiological and psychological significance of event-related potentials, cortical and subcortical recordings are being obtained from monkeys performing in operant-conditioning tasks. Six animals were trained on the cued reaction-time task at SRI International and were subsequently implanted with electrodes capable of recording transient and sustained evoked potentials and massed--unit activity. Two monkeys were trained on an odd-ball task at Stanford University, and electrodes were implanted so that the subcortical generators of the P300 wave could be assessed. At SRI slow potential changes were observed in a variety of cortical and subcortical regions and were observed to change as a function of discrimination, proportionality of stimuli, the interstimulus interval, and dose of an anticholinergic drug.
- Anatomy and Physiology