The Mechanism of Interaction of Oximes with the Muscarinic-Cholinergic Complex in the Central Nervous System
Annual rept. Dec 1982-Nov 1983
TEL-AVIV UNIV (ISRAEL)
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The purpose of the studies described in the present report was to explore the mode of interaction between oximes and acetylcholine ACh muscarinic receptors in the brain. A better understanding of the mechanism of these interactions could help to improve the protection of oxime-muscarinic antagonist mixtures from organophosphate poisoning. In order to achieve these goals, we employed methods based on measurements of the binding of the radiolabeled muscarinic antagonist 3H-4NMPB. The methods employed included both direct binding studies and competition experiments between labeled and unlabeled ligands. The effects of HGG bispyridinium oximes on the binding parameters of muscarinic agonists and antagonists were investigated.