Molecular Interactions of High Energy Fuels and Jet Fuels with Oncogenic Viruses and Endogenous Viruses.
Final rept. 1 Jul 80-30 Sep 83,
OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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The objectives of this research were to develop rapid in-vitro assays, to evaluate the carcinogenic potential of chemicals used by the U.S. Air Force. Snyder-Theilen Feline Sarcoma Virus ST-FeSV, quantitatively transforms human skin fibroblasts following second order kinetics. These studies were performed in order to determine whether chemicals altered ST-FeSV transformation in a predictable manner and to correlate the alteration with the carcinogenic or non-carcinogenic activity of the test chemical. The results, to date, show diverse carcinogens classed as aromatic amines, polycyclic hydrocarbons, aminofluorenes, hydrazines, asbestos and mycotoxins inhibited virus transformation when virus infected cells 2 hours post-infection were exposed to test chemical, while non-carcinogenic chemicals had no significant effect on transformation. Triton X-100, acetone, petroleum and shale oil derived JP5 RJ5 and diesel fuel, marine, demonstrated non-carcinogenic activity while formalin demonstrated carcinogenic activity. Experiments designed to show the specificity of the antagonistic effect of known carcinogens are reported.
- Medicine and Medical Research