Accession Number:

ADA143957

Title:

Multinucleated Giant Cells Induced from Monocyte Precursors by Monoclonal Anti-HLA-DR (Human Ia Antigens) Antibodies.

Descriptive Note:

Technical rept.,

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD DEPT OF PHARMACOLOGY

Personal Author(s):

Report Date:

1984-08-02

Pagination or Media Count:

14.0

Abstract:

Multinucleated giant cells MGC have been observed in inflamed tissues for over a century. MGC form in granulomas caused by bacterial and viral infections and granulomas induced by physical or chemical agents. MGC are also encountered in granulomatous diseases of unknown etiology such as sarcoidosis, rheumatoid arthritis, and Crohns disease. Recent studies have shown that MGC are the result of macrophage fusion. It has been suggested that fusion results when macrophages are overwhelmed with antigen, such as in a granulomatous environment, and several macrophages simultaneously attempt to phagocytose the antigen.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE