Development of Repair Materials for Avulsive Combat-Type Maxillofacial Injuries.
DYNATECH R/D CO CAMBRIDGE MASS
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The objectives for the project to develop a repair material for avulsive combat-type maxillofacial injures have been achieved. A composition containing poly-propylene fumarate, an unsaturated crosslinkable polymer made from fumaric acid, one of the Krebs Cycle acids, and propylene glycol, a commonly used diluent in parenteral drug formulations, along with benzoyl peroxide, vinyl pyrollidone, and an inert filler such as calcium sulfate gypsum has been shown to be easily workable by and, to solidify in 15 minutes at physiological temperatures, and to have physical properties suitable for the intended application. An additional component which may be required to provide adequate shelf-life is a food grade anti-oxidant such as Tenox TBHQ. The results obtained with this composition to date suggest that this material is ready for in vivo evaluation in a suitable animal model.
- Medicine and Medical Research