The Effect of a Low Fluoride Delivery System on Bacterial Metabolism.
Annual rept. 1 Sep 80-30 Jun 81,
CONNECTICUT UNIV HEALTH CENTER FARMINGTON
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The purpose of this contract is to develop and test agents and delivery systems which can prevent and control emergencies in field situations where dental care may be impossible. In this report, three areas are discussed 1 initiation of a clinical trial to test the disease reducing potential of stannous fluoride 2 development and clinical testing of a controlled release delivery system for SnF2 to impart preventive effects without necessity for soldier cooperation and 3 in vitro trials to find the optimum concentration and conditions of SnF2 for disease control as well as exploring other possible agents for these properties. The clinical trial to test the disease reducing potential of SnF2 is now underway with 34 patients, 6 of which have had their 6 month examinations. The patients have been systematically divided into a NaF and a SnF2 group. Pilot studies examining the physical and clinical properties of an intra-coronal controlled release fluoride delivery system were performed. After testing various percentages of SnF2 incorporated into polycarboxylate, zinc phosphate, IRM, and zinc oxide eugenol cements, 70 percent SnF2 in polycarbonxylate cement was found to have adequate compressive strength while releasing the greatest amount of fluoride in vitro.
- Medicine and Medical Research