Korean Hemorrhagic Fever.
Final rept. 1 Jan-31 Dec 81,
KOREA UNIV SEOUL COLL OF MEDICINE
Pagination or Media Count:
Korean hemorrhagic fever KHF is a disease transmitted to man by field nice. Although predominantly associated with rural areas, it is now being recognized as an urban problem in some countries and a particular hazard to laboratory stuff using rodents for biomedical research. Urban rats captured in Seoul and four nearby Korean cities were found to have immunofluorescent antibodies reactive with Hantaan virus, the etilogic agent of KHF. Antibodies were detected in 13 of sera from 477 Rattus norvegicus and 11 of 47 Rattus rattus. Hantaan viral antigen was found in pulmonary tissues of 42 animals and Hantaan virus strains were recovered from 23 rats, all but two of which were R. norvegicus. Wistar rats were qualitatively much more sensitive than Apodemus agrarius rodents for isolation of virus strains from wild rat tissues. Wistar rats inoculated with one of these strains had virus in lung and spleen for at least 75 days. These results document the existence of an urban cycle for Hantaan virus and suggest that Rattus-borne Hantaan virus may be widely distributed in urban centers of Asia and elsewhere.
- Medicine and Medical Research