Accession Number:

ADA143383

Title:

Correlation between Plasma Fibronectin Level and Mortality Following Experimental Rate Heat Stress,

Descriptive Note:

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s):

Report Date:

1984-07-07

Pagination or Media Count:

20.0

Abstract:

Reticuloendothelial system RES clearance function correlates with the mortality rate associated with stresses which can induce shock. Likewise, mortality rate after experimental rat heat stress ERHS is altered by modulation of RES function. Since plasma fibronectin PF mediates in vivo phagocytosis by the RES, the relationship between mean plasma fibronectin level MPFL and mortality after ERHS was examined. A comparison of MPFLs prior to ERHS revealed that rats which ultimately comprised the survival group had a MPFL 269.0 11.2 microgramml which exceeded the value determined for the non-survivors 252.9 or - 11.9 microgramml. Both groups had elevated MPFLs, up to 12 h following ERHS. However, after this time, MPFL began to decline. The decline was more severe for the non-survivors, with MPFLs at 15, 18, and 24 h, significantly p0.01 lower than the values for the survival group.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE