Accession Number:

ADA142952

Title:

The Effect of WR 149024 on Survival Following Hemorrhage in Conscious Rats.

Descriptive Note:

Final rept.,

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s):

• Brown,D. F.
• Bellamy,R. F.

Report Date:

1983-12-01

Pagination or Media Count:

9.0

Abstract:

The effect of WR 149024, an alpha receptor antagonist, on survival following hemorrhage with no volume replacement therapy was investigated. WR 14902 either 5.0 or 50.0 mgkg was administered intraperitoneally to conscious rats during exsanguination. Both WR 149024 treatments caused a significant decrease in survival p0.021, compared with water-injected controls.

Descriptors:

• *DRUGS
• *SHOCK(PATHOLOGY)
• RATS
• PHYSIOLOGICAL EFFECTS
• SURVIVAL(PERSONNEL)
• CHEMOTHERAPY
• BLOOD PLASMA
• BLOOD VOLUME
• HEMORRHAGE

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE