The Effect of WR 149024 on Survival Following Hemorrhage in Conscious Rats.
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The effect of WR 149024, an alpha receptor antagonist, on survival following hemorrhage with no volume replacement therapy was investigated. WR 14902 either 5.0 or 50.0 mgkg was administered intraperitoneally to conscious rats during exsanguination. Both WR 149024 treatments caused a significant decrease in survival p0.021, compared with water-injected controls.