Dermal Sensitization Potential of Insect Repellents: Methyl N,N'-Dihexylethylenediaminemonocarbamate (CHR4), (E)-1,2,3,4-Tetrahydro-6-Methyl-1-(2-Methyl-1-Oxo-2-Butenyl) Quinoline (CHR5), and 1,2,3,4-Tetrahydro-6-Methyl-1-(3-Methyl-1-Oxo-2-Butenyl) Quinoline (CHR6).
Final rept. 8 Sep-25 Oct 82,
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The insect repellents methyl N,Ndihexylethylenediaminemonocarbamate CHR4, E-1,2,3,4-tetrahydro-6-methyl-1-2-methyl-1-oxo-2-butenyl quinoline CHR5, and 1,2,3,4-tetrahydro-6-methyl-1-3-methyl-1-oxo-2-butenyl quinoline CHR6 were tested for dermal sensitization potential using the Guinea Pig Skin Sensitization Test. The study was conducted in compliance with the Good Laboratory Practice regulations. The data collected was analyzed by the method of the U.S. Army Environmental Hygiene Agency. By this method, none of the repellents tested indicated sensitizing potential.