Accession Number:

ADA142442

Title:

The Effects of Hyperbaric Pressure on in vitro Neural Receptors.

Descriptive Note:

Final rept. Aug 80-Sep 83,

Corporate Author:

LITTLE (ARTHUR D) INC CAMBRIDGE MA

Personal Author(s):

Report Date:

1984-06-01

Pagination or Media Count:

61.0

Abstract:

In vitro preparations of the nicotinic acetylcholine receptor from rat muscle and eel electroplax were chemically and pharmacologically characterized and then subjected to compressiondecompression tofrom 800 psi. Pressure causes a reversible decrease in cholinergic agent binding to the receptor. This decrease is prevented if agents such as hexamethonium and diisopropylfluorophosphate are present. These studies imply that pressure effects on molecular interactions at neural receptors could account for hyperbaric neurological disorders. In addition, hyperbaric therapy could be successful in cases of toxin and organophosphorus agent intoxication. Author

Subject Categories:

  • Anatomy and Physiology
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE