Chemical and Molecular Biological Aspects of Alkylhydrazine-Induced Carcinogenesis in Human Cells in Vitro. Revised
Final rept. 1 Jul 1980-30 Sep 1983
OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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The syntheses for 1,1-methyl-14C-dimethylhydrazine, 1,2-methyl- 14C-dimethylhydrazine, and the important metabolite of 1,2-dimethylhydrazine, namley, 14C-methylazoxymethanol as an acetate derivative are described. Materials for high specific activity were employed to 1 Investigate early events in carcinogenesis 2 Study DNA modification and damage and 3 Probe effects of anticarcinogen benzamide, on molecular perturbation of DNA by methylazoxymethanol acetate.