Accession Number:

ADA142428

Title:

Chemical and Molecular Biological Aspects of Alkylhydrazine-Induced Carcinogenesis in Human Cells in Vitro. Revised

Descriptive Note:

Final rept. 1 Jul 1980-30 Sep 1983

Corporate Author:

OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS

Personal Author(s):

Report Date:

1984-04-01

Pagination or Media Count:

78.0

Abstract:

The syntheses for 1,1-methyl-14C-dimethylhydrazine, 1,2-methyl- 14C-dimethylhydrazine, and the important metabolite of 1,2-dimethylhydrazine, namley, 14C-methylazoxymethanol as an acetate derivative are described. Materials for high specific activity were employed to 1 Investigate early events in carcinogenesis 2 Study DNA modification and damage and 3 Probe effects of anticarcinogen benzamide, on molecular perturbation of DNA by methylazoxymethanol acetate.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE