Topical Hazard Evaluation Program of Candidate Insect Repellents of AI3-38359a, AI3-38282.
Final rept. Apr 82-Mar 84,
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
Pagination or Media Count:
These compounds produced no primary irritation of the intact skin and no greater than mild primary irritation of the intact skin and no greater than mild primary irritation of the skin surrounding an abrasion. Chemicals AI3-38359a and AI3-38866a produced mild injury to the cornea and, in addition, some injury to the conjunctiva. Chemicals AI3-38277a, AI3-38865a, and AI3-38866a produced moderate injury to the cornea and, in addition, some injury to the conjunctiva. This injury had healed by 7 days post-application. Chemicals AI3-38859a and AI3-38282 produced moderate to marked sensitization in five of ten, and four of ten, guinea pigs, respectively. The other chemicals did not produce sensitization reactions. All tested chemicals did not cause a photochemical irritation reaction and demonstrated slight to moderate oral toxicity.