Organophosphate Toxicity: Genetics, Receptors, and Antidotes
Annual progress rept. 15 Sep 1982-14 Sep 1983
COLORADO UNIV AT BOULDER INST OF BEHAVIORAL GENETICS
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Studies were completed on the time course of the effect of DFP on brain acetylcholinesterase ACH activity. While brain ACH activity is maximally depressed only 5 minutes after administration, most behavior effects require two or more hours before the maximal effect is seen. Following a 6.33 mgkg dose of DFP the activity of brain ACH does not return to control levels, even after 30 days. This effect is dose-dependent ad affects all brain regions equally. Behavioral studies as well as studies to demonstrate tolerance to DFP have been conducted. Pyridine Chemistry has been studied in an attempt to develop nictonic receptor agonists.