Accession Number:

ADA141059

Title:

Organophosphate Toxicity: Genetics, Receptors, and Antidotes

Descriptive Note:

Annual progress rept. 15 Sep 1982-14 Sep 1983

Corporate Author:

COLORADO UNIV AT BOULDER INST OF BEHAVIORAL GENETICS

Personal Author(s):

Report Date:

1983-11-01

Pagination or Media Count:

44.0

Abstract:

Studies were completed on the time course of the effect of DFP on brain acetylcholinesterase ACH activity. While brain ACH activity is maximally depressed only 5 minutes after administration, most behavior effects require two or more hours before the maximal effect is seen. Following a 6.33 mgkg dose of DFP the activity of brain ACH does not return to control levels, even after 30 days. This effect is dose-dependent ad affects all brain regions equally. Behavioral studies as well as studies to demonstrate tolerance to DFP have been conducted. Pyridine Chemistry has been studied in an attempt to develop nictonic receptor agonists.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE