Biological Applications and Effects of Optical Masers.
Annual rept. 1 Sep 77-31 Aug 78,
MEDICAL COLL OF VIRGINIA RICHMOND
Pagination or Media Count:
The histological investigations of the photochemical lesion produced in the rhesus retina by blue light 441 nm have been completed for post-exposure times ranging from one hour to ninety days. Ultrastructural studies of the lesion by transmission EM are well advanced for periods of 2, 5, and 6 days postexposure. Spectral sensitivity tests at 20 nm intervals have been completed for the spectral range 420-620 nm on two animals. The latency of response to the light stimulus has been studied on three animals. To further elucidate the differential effects on the retina of short vs long wavelength CW radiation the simulated solar spectrum 300-1400 nm was divided into two spectral bands, 400-800 nm and 700-1400 nm. The radiant exposures required to produce very mild lesions in 1, 10, 100 and 1000 s were determined on eight rhesus monkeys for each spectrum, i.e. 300-1400 nm, 400-800 nm, 700-1400 nm. An additional study is being conducted to determine the radiant exposures required to produce a mild retinal lesion in the waveband 400-735 nm by using nine sharp cut filters.