In-Vivo Techniques for Measuring Electrical Properties of Tissues.
Annual rept. 1 Jul 79-30 Jun 80,
GEORGIA INST OF TECH ATLANTA ENGINEERING EXPERIMENT STATION
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The overall objectives of this research investigation are to further develop and extend the capabilities of the recently-developed in-vivo probe measurement technique and to use this technique to study the possible effects of induced physiological changes on tissue dielectric properties. During the second year of the program, the research investigations performed included 1 development of techniques to further reduce systemic measurement errors, 2 development of a method for maintaining uniform probe contact pressure during in-situ dielectric measurements of tissue, 3 examination of the potential necessity of time-locking data sampling to the animals respiratory cycle, 4 studies of antemortempostmortem dielectric characteristics of the pial surface of dog brain, 5 investigations of the effects of changing renal blood flow on kidney dielectric properties, and 6 initial studies of the effects of auditory stimulation on dielectric properties of the auditory cortex in dogs. Significant changes in dielectric properties of dog cortex were observed as a function of time postmortem sacrifice using KCl and CaCl2 produced different effects on dielectric properties immediately post injection which were consistent with their different mechanisms of physiological action. Mean changes in dielectric constant and electrical conductivity postmortem were 9.5 and 16.5, respectively.
- Anatomy and Physiology