Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-38274, AI3-38276, and AI3-38279, US Department of Agriculture Proprietary Chemicals, February - November 1983.
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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The technical grade chemicals produced no greater than mild primary irritation of the intact skin and of the skin surrounding an abrasion. The 24 percent wv solutions of these chemicals in 95 percent ethanol which were applied during photoirritation studies produced mild to moderate primary irritation of the intact skin, without ultraviolet UV irradiation. Chemical AI3-38276 produced a photochemical irritant reaction upon irradiation with UV light which was significantly more severe than the primary irritation previously noted. Additionally, although these ethanol solutions were colorless, they produced a marked yellow discoloration of the skin upon application. All three chemicals produced moderate injury to the cornea and, in addition, produced some injury to the conjunctiva.