The Role of Newly Discovered Exotoxin (S Toxin) in Pseudomonas aeruginosa Infections
Annual rept. 1 Aug 1979-31 Jul 1980
OREGON UNIV HEALTH SCIENCES CENTER PORTLAND
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The goal is to determine the role of exotoxin S in humans infected with Pseudomonas aeruginosa and develop vaccines to reduce the morbidity and mortality associated with these infections. During the period we have 1 Developed a specific assay for S which allows us to distinguish between the enzymatic activities of toxins A and S. 2 Utilized the above assay to determine the percentage of clinical isolates of P. aeruginosa which produce S. 3 Purified analytical amounts of S, determined its molecular weight and used the pure S to raise specific S antibodies in rabbits. 4 Developed a defined medium for the production of S by P. aeruginosa strain 388-6. 5 Continued studies on the large scale purification of S. 6 Purified several large batches of P. aeruginosa toxin A and diphtheria toxin.
- Medicine and Medical Research