Accession Number:

ADA139455

Title:

The Role of Endorphins in the Pathophysiology of Hemorrhagic and Endotoxic Shock in the Primate.

Descriptive Note:

Rept. no. 1 (Annual) 1 Jun 80-1 Jun 81,

Corporate Author:

IOWA UNIV IOWA CITY COLL OF MEDICINE*

Personal Author(s):

Report Date:

1981-07-01

Pagination or Media Count:

16.0

Abstract:

In order to investigate the possible role and involvement of endogenous morphine-like substance endorphins in shock we studied cynomulgus monkeys subjected to hemorrhagic and endotoxemic shock. Blockade of opiate receptors with naloxone improved cardiovascular performance and survival in endotoxemic shock but produced only mild improvement in cardiovascular function and no increased survival in hemorrhagic shock. We conclude that endorphin systems are activated in and contribute to the cardiovascular depression in primate shock. Further work in his area is justified including development of a better primate hemorrhagic shock model.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE