A Study on the Gastrointestinal Hormones and the Gastric Acid Secretion during Physical Stress in Man,
NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT KJELLER
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In the present thesis, we have studied the effect of prolonged physical stress and absolute fasting on the blood levels of gastrointestinal peptides and the secretion of gastric acid. Especial attention has been paid to peptide levels that influence, or influenced by, the secretion of gastric acid gastrin, secretion, pepsinogens I, or that probably have metabolic function vasoactive intestinal polypeptide, pancreatic polypeptide. The hyperchlorhydria was not caused by the gastrin hormone, but the hyperchlorhydria of gastric acid could account for approximately fifty per cent of the hypersecretinemia found during the stress. High plasma levels of secretion were also found during a 4-5 day period of absolute fasting. The high plasma levels of vasoactive intestinal polypeptide VIP were not influenced by the gastric acid secretion. Instead, the results indicated that VIP is a peptide of substrate need. The high fasting serum levels of human pancreatic polypeptide were modified by nutrient ingestion both during physical stress and absolute fasting.