Clinical Evaluation of Acidulated-Phosphate-Fluoride in the Navy's Preventive Dentistry Program
NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
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The stannous fluoride used in the Navys preventive dentistry program has certain objectionable features unpleasant taste and a tendency to stain the teeth. A study was designed to assess the feasibility of substituting acidulated-phosphate-fluoride which is reported to be as effective as stannous fluoride but does not possess the objectionable features. Naval recruits were used as subjects and were placed in three groups stannous fluoride, acidulated- phosphate-fluoride and a placebo control. Assessments of effectiveness were based on caries increments in the posterior interproximal teeth surfaces during a one-year period. It was discovered that the groups were initially noncomparable and the study essentially yielded no meaningful results. The study is reported for historical interest and as an example of clinical trial hazards.
- Medicine and Medical Research