Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-38225a, AI3-38192a, AI3-38194a, AI3-38599a, and AI3-38427a.
Final rept. Jun 81-Nov 83,
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
Pagination or Media Count:
Chemicals AI3-38192a, AI3-38599a, and AI3-38427a produced no primary skin irritation. Chemicals AI3-38225a and AI3-38194a produced mild irritation of the intact skin and the skin surrounding an abrasion. Chemical AI3-38599a was noninjurious to the eyes of rabbits. Chemical AI3-38192a produced mild injury to the cornea chemicals AI3-38225a, AI3-38427a, and AI3-38194a produced mild injury to the cornea and, in addition, some injury to the conjunctiva upon application to the eues of rabbits. Chemicals AI3-38225a, AI3-38192a, AI3-38599a, and AI3-38427a did not produce a sensitization reaction. Chemical AI3-383194a produced a slight sensitization reaction in 6 of the 10 guinea pigs tested. All chemicals were relatively nontoxic by ingestion and did not potentiate photoirritation. Recommended that chemicals AI3-38225a, AI3-38192a, AI3-38599a, and AI3-38427a be approved for further testing as candidate insect repellants. Recommended that chemical AI3-38194a be disapproved for further testing due to its sensitizing potential.