The Role of Intestinal Bacteria in Acute Diarrheal Diseases
Annual rept. Jul 1975-Jun 1977
TUFTS-NEW ENGLAND MEDICAL CENTER BOSTONMA
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This report describes investigations in these four major areas of research 1 Reassessment of the infant rabbit model of E. coli colonization. 2 Testing of E. coli strains isolated from humans with diarrheal disease for enterotoxin production and presence of colonization-specific surface antigens. 3 Methodology for isolation of specific pili i.e. surface antigens which function in colonization. Characterization of pili. Preparation of pili- specific antisera. 4 In vitro adhesion assays specific for recognition of E. coli strains which are potentially pathogenic for humans.
- Medicine and Medical Research