Toxicokinetic Principles in Relation to Percutaneous Absorption and Cutaneous Toxicity
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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At the foundation of the sciences of toxicology and pharmacology is the concept that coherent dose-response relationships exist for describing effects of chemicals on biological organisms. In one of several forms, dose-response curves for quantal effects are constructed by plotting the proportion of animals in a group responding with a particular effect on a y-axis, e.g., a dermal effect such as chloracne, versus the logarithm of dose on the x-axis. The resulting curve has a sigmoidal shape and usually progresses smoothly from no response at low concentration to 100 response at sufficiently high concentration. Although this is the usual shape for quantal dose-effect relationships, curves with anomalous shapes are not unknown, and such behavior usually gives significant information about mechanisms of the biological effect under investigation.