The Chemical Characteristics of PGBx.
Final progress rept.,
MASSACHUSETTS INST OF TECH CAMBRIDGE DEPT OF CHEMISTRY
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It was first attempted to separate PGBx, a biologically active material obtained upon alkali treatment of 15-keto-prostaglandin-B11, into its components, determine their molecular weight and, finally, molecular structure. When it became clear that PGBx is too complex a mixture, model studies were begun. To investigate the mechanism by which the chemically active moiety in 15-keto-prostaglandin-B1 oligomerizes to PGBx under alkaline conditions, the condensation of 3-ethyl-4-3-ketopenten-1-yl cyclopent-2-enone 2 was investigated.