Accession Number:

ADA135851

Title:

The Chemical Characteristics of PGBx.

Descriptive Note:

Final progress rept.,

Corporate Author:

MASSACHUSETTS INST OF TECH CAMBRIDGE DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1983-08-18

Pagination or Media Count:

3.0

Abstract:

It was first attempted to separate PGBx, a biologically active material obtained upon alkali treatment of 15-keto-prostaglandin-B11, into its components, determine their molecular weight and, finally, molecular structure. When it became clear that PGBx is too complex a mixture, model studies were begun. To investigate the mechanism by which the chemically active moiety in 15-keto-prostaglandin-B1 oligomerizes to PGBx under alkaline conditions, the condensation of 3-ethyl-4-3-ketopenten-1-yl cyclopent-2-enone 2 was investigated.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE