Investigation of Immunoregulatory Alphaglobulin (IRA) in Shock and Trauma.
Annual progress rept. 1 Jul 80-30 Jun 81,
BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
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The major research accomplishment of the past year included the determination that serum immunosuppressive activity was highly correlated with cutaneous anergy in a series of 21 burn patients with greater than 30 body surface area burn. Anergy in these patients also was significantly correlated with impairment of the response of peripheral blood lymphocytes to PHA stimulation. Low molecular weight peptide containing factions obtained from the serum of burn and trauma patients consistently suppressed the ability of mice to resist challenge with Listeria monocytogenes organisms. Mice injected with this material demonstrated suppressor cell activity in their spleens as evidenced by the effect of their splenocytes on the response of syngeneic spleen cells to mitogens and antigens. Author
- Medicine and Medical Research