Biochemical Basis of Virulence in Epidemic Typhus.
Annual rept. Aug 80-Apr 81, Final rept. 1 Feb 79-30 Apr 81,
UNIVERSITY OF SOUTH ALABAMA MOBILE COLL OF MEDICINE
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The purpose of the project is to elucidate the biochemical basis of virulence in epidemic typhus. The basic method is a comparison of the E strain and Breninl strain avirulent and virulent, respectively of Rickettsia prowazekii in their interaction with the host defense system. Subsequent to the last annual report, work has focused on two areas 1 a study of the ability of virulent and avirulent Rickettsia prowazekii in the cytoplasm of macrophage-like cell lines which employed a fusion technology and 2 the preparation of a manuscript on the macrophage-like cell lines ability to differentiate the virulent and avirulent typhus rickettsiae.
- Medicine and Medical Research